Modeling approaches for early warning and monitoring of pandemic situations as well as decision support
Publisher: Frontiers in Public HealthAuthors: J. Botz, D. Wang, N. Lambert, N. Wagner, M. Génin, E. Thommes, S. Madan, L. Coudeville, H.Fröhlich View publication The COVID-19 pandemic has highlighted the lack of preparedness of many healthcare systems against pandemic situations. In response, many population-level computational modeling approaches have been proposed for predicting outbreaks, spatiotemporally forecasting disease spread, and […]
Epidemiology, treatment patterns, clinical outcomes, and disease burden among patients with immune‐mediated thrombotic thrombocytopenic purpura in the United States
Publisher: Research and practice in thrombosis and haemostasis (rpth)Authors: A. Adeyemi, F. Razakariasa, A. Chiorean, R. de Passos Sousa View publication Background Immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a life‐threatening thrombotic microangiopathy. Due to its rarity, epidemiology and real‐world outcomes data are scarce. Objectives The aim was to assess epidemiology, treatment patterns, clinical outcomes, and […]
Identifying patients with Gaucher Disease type 3 (GD3) in the Optum’s de-identified Market Clarity database: a clustering analysis
Event: WORLD Symposium 2022, San Diego, CA, USA Authors: C. Rochmann, M. Génin, M. Blanchon, N. Lambert, L. Deplante, W. Heine, S.Kabadi View Poster Objectives GD3 is a progressive, Lysosomal Storage Disorder (LSD), distinguished from GD1 by early heterogenous neurological manifestations. Neurological presentation in GD1 patients is not well understood. Differentiation of GD3 from GD1 […]
Clustered analysis of Fabry disease progression in a large US electronic health records database (Optum Market Clarity): A retrospective observational cohort study
Event: WORLD Symposium 2022, San Diego, CA, USA Authors: A. Chiorean, S. Kabadi, P. Hayat, M. Montmerle, E. Ponce, M. Blanchon, N. Lyn, M. Maski View Poster Introduction: As the spectrum of Fabry phenotypes remains uncertain, the study objective was to describe patterns of progression in untreated Fabry disease (FD) patients from a large electronic […]
Assay Harmonization and Use of Biological Standards To Improve the Reproducibility of the Hemagglutination Inhibition Assay: a FLUCOP Collaborative Study
Publisher: ASM Journals / mSphereAuthors: J. Waldock, L. Zheng, E.J. Remarque, A. Civet, B. Hu, S. Lartey Jalloh, R. Jane Cox, S. Ho, K. Hoschler, T. Ollinger, C.M. Trombetta, O.G. Engelhardt, C.Caillet View publication Background The hemagglutination inhibition (HAI) assay is an established technique for assessing influenza immunity, through measurement of antihemagglutinin antibodies. Improved reproducibility of […]
Social deprivation aggravates post-operative morbidity in carcinologic colorectal surgery: Results of the COINCIDE multicenter study
Publisher: Journal of Visceral SurgeryAuthors: A. Alves, A. Civet, A. Laurent, Y. Parc, C. Penna, S. Msika, M. Hirsch, M. Pocard, G. Coincide View publication Aim of the study Evaluate the impact of social deprivation on morbidity and mortality in surgery for colorectal cancer. Methods The COINCIDE prospective cohort included nearly 2,000 consecutive patients operated on […]
Q-Finder: An Algorithm for Credible Subgroup Discovery in Clinical Data Analysis — An Application to the International Diabetes Management Practice Study
Publisher: Frontiers Artificial IntelligenceAuthors: C. Esnault, M-L. Gadonna, M. Queyrel, A. Templier, J-D. Zucker View publication Background Addressing the heterogeneity of both the outcome of a disease and the treatment response to an intervention is a mandatory pathway for regulatory approval of medicines. In randomized clinical trials (RCTs), confirmatory subgroup analyses focus on the assessment of drugs in […]
Rationale and methodology for a European pooled analysis of post-marketing interventional and observational studies of insulin glargine 300 U/mL in diabetes: the REALI project
Publisher: BMJ openAuthors: N. Freemantle, R.C. Bonadonna, P. Gourdy, D. Mauricio, D. Mueller-Wieland, G. Bigot, A. Ciocca, C. Mauquoi, M. Rollot, M. Bonnemaire View publication Introduction Type 2 diabetes mellitus (T2DM) is a common and heterogeneous disease. Using advanced analytic approaches to explore real-world data may identify different disease characteristics, responses to treatment and progression patterns. Insulin glargine 300 units/mL (Gla-300) is a second-generation […]
Identification of predictive factors of DKA using a subgroup discovery algorithm
Event : EASD (European Association for the Study of Diabetes) Annual Meeting 2019, Barcelona, SpainAuthors: Angela Ibald-Mulli, Margot Blanchon, Alexandre Civet, Julia Hermann, Simon Gosset, Oussama Berguiga, Dieter Paar View video View publication Background and aims: Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes (T1D), which is difficult to diagnose due to […]
Unmet medical needs in people with type 2 diabetes treated by insulin: results from the International Diabetes Management Practices Survey (IDMPS)
Event: EASD (European Association for the Study of Diabetes) Annual Meeting 2019, Barcelona, SpainAuthors: A. Ramachandran, JC. Mbanya, P. Aschner, JJ. Gagliardino, H. Ilkova, F. Lavalle, M; Shestakova, J-M. Chantelot, A. Shaunik, A. Alvarez, M. Rollot, J. CN Chan View Poster Background and aims Limited data exist on the impact of different insulin therapy regimes on […]
