Existing automated tools to assist evidence generation and better qualification of registries and real-world data. A systematic review from the More-EUROPA project
Event: ISPOR Europe 2023, Copenhagen, Denmark Authors: P. Godbillot, P. Tang, J. Moreira, J. Tanniou S. Zebachi, B. Amzal View Poster Objectives The More-EUROPA project consortium brings together 14 public and private entities from 7 countries with the aim of enhancing the ethical and effective utilization of registry data to facilitate patient-centered decision-making by drug regulators and Health Technology Assessment […]
Artificial Intelligence (AI) ToOLs for Outbreak Detection and response: a transnational platform for surveillance, monitoring and decision support
Event: ISPOR Europe 2023, Copenhagen, Denmark Authors: M. Génin, J. Botz, L. Coudeville, M. Eisenlauer, T. Fauvel, F. Huschka, N. Lambert, D. Wang, V. Bosch Castells, C. Commaille-Chapus, B. Frandji, M. Haberstroh, JY. Robin, P. Roehn, H. Sippel, P. Thiele, E. Thommes, C. Weber, B. Amzal, H. Fröhlich, A. Kannt, C. Mahé View Poster Objectives […]
Machine learned decision tree for diagnosis of ASMD among patients with unexplained Interstitial Lung Disease
Event: European Respiratory Society (ERS) International Congress 2023, Milan, Italy Authors: I. Noth, F. Bonella, W.A. Wuyts,P. Guilmin, M. Törnqvist, S. Sansen, A. Dumitriu, N. Shah, M. Gasparic, M. Montmerle View Poster Background Patients with acid sphingomyelinase deficiency (ASMD), a rare lysosomal storage disease, suffer interstitial lung disease (ILD) as a common clinical manifestation. Patients […]
Development of a rare disease algorithm to identify persons at risk of Gaucher disease using Electronic Health Records (EHR) in the United States
Publisher: Orphanet Journal of Rare DiseasesAuthors: A. Wilson, A. Chiorean, M. Aguiar, D. Sekulic, P. Pavlick, N. Shah, L. Sniderman King, M. Génin, M. Rollot, M. Blanchon, S. Gosset, M. Montmerle, C. Molony, A. Dumitriu View publication Background Early diagnosis of Gaucher disease (GD) allows for disease-specific treatment before significant symptoms arise, preventing/delaying onset of complications. Yet, […]
Enhancing Real-World Evidence with Biomedical Knowledge Graphs: Exploring Atopic Dermatitis Endotypes
Event: ISMB/ECCB 2023, Lyon, France Authors: F. Frau, P. Loustalot, M. Törnqvist, N. Temam, J. Cupe, F. Augé View Poster Background Precision Medicine is defined by the U.S. Food & Drug Administration as “an innovative approach to tailoring disease prevention and treatment that considers differences in people’s genes, environments and lifestyles. Methods To succeed in […]
AliBERT: A pretrained Language Model for French Biomedical Text
Event : BioNLP 2023 Workshop at ACL (Association for Computational Linguistics)Authors: A. Berhe, G. Draznieks, V. Martenot, V. Masdeu, L. Davy, J-D. Zucker View publication Background Over the past few years, domain specific pretrained language models have been investigated and have shown remarkable achievements in different downstream tasks, especially in biomedical domain. These achievements stem on the well known BERT […]
L’intelligence artificielle au service de la modélisation de maladies en vie réelle : vision, exemples et impact sur l’évaluation des médicaments
Event: Colloque de Données de Santé en vie réelle, AFCROs 2023, Boulogne-Billancourt, France Authors: M. Génin, M. Rollot, A. Movschin, B. Amzal, J. Tanniou View Poster Introduction Le rôle des données de vie réelle (RWD) devient de plus en plus important dans les évaluations réglementaires et HTA, en compléments des essais randomisés (RCT), notamment pour anticiper […]
AI/ML in Precision Medicine: A Look Beyond the Hype
Publisher: Therapeutic Innovation & Regulatory Science (Springer Nature Link)Authors: Z. Xu, B. Biswas, L. Li, B. Amzal View publication Background Artificial Intelligence (AI) and Machine Learning (ML) are making headlines in medical research, especially in drug discovery, digital imaging, disease diagnostics, genetic testing, and optimal care pathway (personalized care). Patients and methods However, the potential uses and […]
Hemolytic Markers, Mortality and Thromboembolic events in Cold Agglutinin Disease (CAD) with risk assessment by disease duration
Event: European Hematology Association (EHA) Congress 2023, Frankfurt, Germany Authors: Q.A. Hill, W. Barcellini, A. Röth, A. Karaouni, M. Afonso, R. Yoo, J. Tanniou, J. Rubio, C. Broome View Poster Background Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia (AIHA) characterized by classical complement pathway-mediated hemolysis. Although there is consensus on an increased […]
High-Dose Influenza Vaccine Is Associated With Reduced Mortality Among Older Adults With Breakthrough Influenza Even When There Is Poor Vaccine-Strain Match
Publisher: Clinical Infectious DiseasesAuthors: S.S. Chaves, S. Naeger, K. Lounaci, Y. Zuo, M.M. Loiacono, Q. Pilard, J. Nealon, M. Génin, C. Mahe View publication Background High-dose (HD) influenza vaccine offers improved protection from influenza virus infection among older adults compared with standard-dose (SD) vaccine. Here, we explored whether HD vaccine attenuates disease severity among older adults with breakthrough influenza. […]
