A text-to-tabular approach to generate synthetic patient data using LLMs
Publisher: arXivAuthors: Margaux Tornqvist, Jean-Daniel Zucker, Tristan Fauvel, Nicolas Lambert, Mathilde Berthelot, Antoine Movschin View publication Abstract Access to large-scale high-quality healthcare databases is key to accelerate medical research and make insightful discoveries about diseases. However, access to such data is often limited by patient privacy concerns, data sharing restrictions and high costs. To overcome […]
Development of a rare disease algorithm to identify persons at risk of Gaucher disease using Electronic Health Records (EHR) in the United States
Publisher: Orphanet Journal of Rare DiseasesAuthors: A. Wilson, A. Chiorean, M. Aguiar, D. Sekulic, P. Pavlick, N. Shah, L. Sniderman King, M. Génin, M. Rollot, M. Blanchon, S. Gosset, M. Montmerle, C. Molony, A. Dumitriu View publication Background Early diagnosis of Gaucher disease (GD) allows for disease-specific treatment before significant symptoms arise, preventing/delaying onset of complications. Yet, […]
AliBERT: A pretrained Language Model for French Biomedical Text
Event : BioNLP 2023 Workshop at ACL (Association for Computational Linguistics)Authors: A. Berhe, G. Draznieks, V. Martenot, V. Masdeu, L. Davy, J-D. Zucker View publication Background Over the past few years, domain specific pretrained language models have been investigated and have shown remarkable achievements in different downstream tasks, especially in biomedical domain. These achievements stem on the well known BERT […]
AI/ML in Precision Medicine: A Look Beyond the Hype
Publisher: Therapeutic Innovation & Regulatory Science (Springer Nature Link)Authors: Z. Xu, B. Biswas, L. Li, B. Amzal View publication Background Artificial Intelligence (AI) and Machine Learning (ML) are making headlines in medical research, especially in drug discovery, digital imaging, disease diagnostics, genetic testing, and optimal care pathway (personalized care). Patients and methods However, the potential uses and […]
High-Dose Influenza Vaccine Is Associated With Reduced Mortality Among Older Adults With Breakthrough Influenza Even When There Is Poor Vaccine-Strain Match
Publisher: Clinical Infectious DiseasesAuthors: S.S. Chaves, S. Naeger, K. Lounaci, Y. Zuo, M.M. Loiacono, Q. Pilard, J. Nealon, M. Génin, C. Mahe View publication Background High-dose (HD) influenza vaccine offers improved protection from influenza virus infection among older adults compared with standard-dose (SD) vaccine. Here, we explored whether HD vaccine attenuates disease severity among older adults with breakthrough influenza. […]
Estimating the pertussis burden in adolescents and adults in the United States between 2007 and 2019
Publisher: Taylor & Francis OnlineAuthors: D. Macina, S. Mathur, M. Dvaretskaya, S. Ekhtiari, P. Hayat, M. Montmerle, C.Daluwatte View publication Objectives We developed a machine learning algorithm to identify undiagnosed pertussis episodes in adolescent and adult patients with reported acute respiratory disease (ARD) using clinician notes in an electronic healthcare record (EHR) database. Here, we utilized the algorithm to […]
Development of an algorithm for finding pertussis episodes in a population-based electronic health record database
Publisher: Taylor & Francis OnlineAuthors: C. Daluwatte, M. Dvaretskaya, S. Ekhtiari, P. Hayat, M. Montmerle, S. Mathur, D. Macina View publication Background While tetanus-diphtheria-acellular pertussis (Tdap) vaccines for adolescents and adults were licensed in 2005 and immunization strategies proposed, the burden of pertussis in this population remains under-recognized mainly due to atypical disease presentation, undermining efforts to optimize protection […]
Cluster analysis of kidney function decline among males with Fabry disease in a large United States electronic health records database
Publisher: ndt (Nephrology Dialysis Transplantation)Authors: A. Chiorean, N. Lyn, S. Kabadi, M. Blanchon, P. Hayat, P. Loustalot, M. Maski, M. Montmerle, E. Ponce View publication Background Fabry disease (FD) is an X-linked lysosomal storage disorder caused by deficient α-galactosidase A activity. The spectrum of disease includes phenotypes ranging from ‘classic’ to ‘later-onset’, with varying kidney disease progression. Identifying patterns of declining kidney function […]
Identification of Predictive Factors of Diabetic Ketoacidosis in Type 1 Diabetes Using a Subgroup Discovery Algorithm
Publisher: Diabetes, Obesity and MetabolismAuthors: Angela Ibald-Mulli, Jochen Seufert, Julia M. Grimsmann, Markus Laimer, Peter Bramlage, Alexandre Civet, Margot Blanchon, Simon Gosset, Alexandre Templier, W. Dieter Paar, Fang Liz Zhou, Stefanie Lanzinger View publication Aim To identify predictive factors for diabetic ketoacidosis (DKA) by retrospective analysis of registry data and the use of a subgroup […]
Qluster: An easy-to-implement generic workflow for robust clustering of health data
Publisher: Frontiers in Artificial IntelligenceAuthors: C. Esnault, M. Rollot, P. Guilmin, J-D. Zucker View publication Background The exploration of heath data by clustering algorithms allows to better describe the populations of interest by seeking the sub-profiles that compose it. This therefore reinforces medical knowledge, whether it is about a disease or a targeted population in real life. Nevertheless, […]
